D Site Of Albumin Promoter Binding Protein (DBP)

DBP is a member of the PAR bZIP (proline and acidic amino acid-rich basic leucine zipper) transcription factor family.The deduced 325-amino acid protein contains PAR, DNA-binding, and leucine zipper domains in its C-terminal half. Northern blot analysis detected a 1.8-kb transcript in all cell lines and tissues tested except liver, which appeared to contain degraded DBP mRNA.

Genes regulated by the PAR bZIP transcription factors showed similar circadian cycles of expression, with higher amplitude in mouse liver. Transcriptome profiling revealed that pyridoxal kinase (PDXK), a coenzyme of many enzymes involved in amino acid and neurotransmitter metabolism, is a target gene for PAR bZIP proteins in liver and brain.