DEAH Box Polypeptide 36 (DHX36)

DHX36 is a member of the DEAH-box family of RNA-dependent NTPases which are named after the conserved amino acid sequence Asp-Glu-Ala-His in motif II. The protein encoded by this gene has been shown to enhance the deadenylation and decay of mRNAs with 3'-UTR AU-rich elements (ARE-mRNA). The protein has also been shown to resolve into single strands the highly stable tetramolecular DNA configuration (G4) that can form spontaneously in guanine-rich regions of DNA. DHX36 showed robust G4-DNA resolving activity. Formation of DNA monomers by DHX36 required ATP and Mg(2+). DHX36 did not resolve Y-form duplex DNA or duplex DNA with 5-prime or 3-prime overhangs. DHX36 readily resolved ribosomal G4-DNA.