DIX Domain Containing Protein 1 (DIXDC1)

The 3-prime UTR of the cDNA contains an Alu element, and the deduced protein contains 493 amino acids. RT-PCR ELISA detected high expression in adult whole brain and in several specific brain regions. Intermediate expression was detected in all other tissues and brain regions examined.

The deduced 472-amino acid DIXDC1 protein has a central myosin tail homology (MTH) region similar to those found in MYH1 and MYH2, as well as a C-terminal DIX domain. Within the MTH region, DIXDC1 contains 2 tyrosine phosphorylation sites and a leucine zipper motif. DIXDC1 was predicted to be a cytoplasmic protein.In contrast with human DIXDC1, the MTH region of mouse Dixdc1 has only 1 tyrosine phosphorylation site and no leucine zipper motif.