Defensin Beta 132 (DEFb132)
DEFB32; Defensin HEL-75
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In primates, infection is an important force driving gene evolution, and this is reflected in the importance of infectious disease in human morbidity today. The beta-defensins are key components of the innate immune system, with antimicrobial and cell signalling roles, but also reproductive functions. Five beta-defensin genes that do not show copy number variation in humans show evidence of positive selection in catarrhine primates, and identify specific codons that have been under selective pressure. Direct haplotyping of DEFB127 in humans suggests long-term balancing selection: there are two highly diverged haplotype clades carrying different variants of a codon that, in primates, is positively selected. For DEFB132, Extensive diversity, including a four-state amino acid polymorphism, is present in hunter-gatherer populations, both African and non-African, but not found in samples from agricultural populations.
Organism species: Homo sapiens (Human)
- Customized Service n/a Recombinant Defensin Beta 132 (DEFb132) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Defensin Beta 132 (DEFb132) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Defensin Beta 132 (DEFb132) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Defensin Beta 132 (DEFb132) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Defensin Beta 132 (DEFb132) ELISA Kit Customized Service Offer