Exenatide (EXT)
Byetta; Bydureon; Exendin-4
Exenatide is a 39-amino-acid peptide, an insulin secretagogue, with glucoregulatory effects. The incretin hormones GLP-1 and glucose-dependent insulinotropic peptide (GIP) are produced by the L and K endocrine cells of the intestine following ingestion of food. GLP-1 and GIP stimulate insulin secretion from the beta cells of the islets of Langerhans in the pancreas. Only GLP-1 causes insulin secretion in the diabetic state; however, GLP-1 itself is ineffective as a clinical treatment for diabetes as it has a very short half-life in vivo. Exenatide bears a 50% amino acid homology to GLP-1 and it has a longer half-life in vivo. Thus, it was tested for its ability to stimulate insulin secretion and lower blood glucose in mammals, and was found to be effective in the diabetic state. In studies on rodents, it has also been shown to increase the number of beta cells in the pancreas.
Organism species: Pan-species (General)
- Conjugated small molecules CPV768Ge11 BSA Conjugated Exenatide (EXT) In Stock
- Monoclonal antibody MAV768Ge21 Monoclonal Antibody to Exenatide (EXT) In Stock
- Monoclonal antibody MAV768Ge22 Monoclonal Antibody to Exenatide (EXT) In Stock
- Customized Service n/a CLIA Kit for Exenatide (EXT) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Exenatide (EXT) ELISA Kit Customized Service Offer