Family With Sequence Similarity 188, Member B (FAM188B)

Fam188a and its paralogs in other species are all members of the DUF4205 superfamily of protein domains. Fam188a is a highly conserved gene found in all vertebrates. Fam188a is a gene expressed throughout the body. All mammalian species compared share a 95-99% homology similarity to Homo sapiens Fam188a. The reasons behind this are unknown, but it can be inferred that Fam188a must play an important role in proper cellular function in mammals, as even small changes over time in important genes can drastically alter their function. Fam188a is a 445-Amino Acid chain. Structurally, it doesn't show many interesting regions that could easily set it apart from other proteins. Fam188a has no transmembrane domains, it has no sequence repeats.