Fas Associating Death Domain Containing Protein (FADD)
GIG3; MORT1; FADD Death Effector Domain; Fas-Associated Protein With Death Domain; Mediator Of Receptor-Induced Toxicity; Growth-Inhibiting Gene 3
FADD is an adaptor molecule that bridges the Fas-receptor, and other death receptors, to caspase-8 through its death domain to form the death inducing signaling complex during apoptosis. The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade.
Organism species: Homo sapiens (Human)
- Recombinant protein RPK078Hu01 Recombinant Fas Associating Death Domain Containing Protein (FADD) In Stock
- Polyclonal antibody PAK078Hu01 Polyclonal Antibody to Fas Associating Death Domain Containing Protein (FADD) In Stock
- Sandwich ELISA SEK078Hu ELISA Kit for Fas Associating Death Domain Containing Protein (FADD) In Stock
Organism species: Mus musculus (Mouse)
- Recombinant protein RPK078Mu01 Recombinant Fas Associating Death Domain Containing Protein (FADD) In Stock
- Polyclonal antibody PAK078Mu01 Polyclonal Antibody to Fas Associating Death Domain Containing Protein (FADD) In Stock
- Customized Service n/a CLIA Kit for Fas Associating Death Domain Containing Protein (FADD) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Fas Associating Death Domain Containing Protein (FADD) ELISA Kit Customized Service Offer
Organism species: Rattus norvegicus (Rat)
- Customized Service n/a Recombinant Fas Associating Death Domain Containing Protein (FADD) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Fas Associating Death Domain Containing Protein (FADD) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Fas Associating Death Domain Containing Protein (FADD) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Fas Associating Death Domain Containing Protein (FADD) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Fas Associating Death Domain Containing Protein (FADD) ELISA Kit Customized Service Offer