Free Fatty Acid Receptor 2 (FFAR2)

The physiologic responses to galanin (GAL) are mediated through specific membrane receptors called GALRs, which are members of the G protein-coupled receptor (GPCR) family. One product contained a segment showing 100% homology to a portion of the 3-prime region of the human CD22 gene . The authors identified a PAC clone in the sequence databases that overlaps this region and contains a novel putative GPCR gene, GPR43.

The intronless GPR43 gene is located approximately 77 kb downstream of the GPR42 gene . GPR43 encodes a deduced 330-amino acid protein with 7 transmembrane domains. The GPR43 protein shares 28% amino acid identity with GPR40and little similarity with GALRs.