Fucosyltransferase 2 (FUT2)

The classic human secretor locus (Se) FUT2 encodes alpha-(1,2)fucosyltransferase, which regulates expression of the Lewis ABO(H) histo-blood group antigens on the surface of epithelial cells and in body fluids and determines the secretion status of the ABO antigens. Secretor status of this polymorphic protein was used by Mohr (1951) to provide the first autosomal linkage in humans between secretor factor and the Lutheran blood group.

The secretor factor (Se) might be considered either a physiologic trait or an honorary blood group (VAM). The individual who is a so-called secretor has demonstrable ABH blood group antigen in the saliva and other body fluids; the nonsecretor does not. Secretor is dominant.