G Protein Alpha Stimulating Activity Polypeptide 1 (GNaS1)

NESP55; NESP; GNASXL; GPSA; SCG6; Secretogranin VI; Adenylate cyclase-stimulating G alpha protein; Guanine Nucleotide Binding Protein Alpha Stimulating Activity Polypeptide 1

G Protein Alpha Stimulating Activity Polypeptide 1 (GNaS1)
GNAS is a complex imprinted locus that produces multiple transcripts through the use of alternative promoters and alternative splicing. The most well-characterized transcript derived from GNAS, Gs-alpha, encodes the alpha subunit of the stimulatory guanine nucleotide-binding protein (G protein). Gs-alpha is expressed biallelically in nearly all tissues and plays essential roles in a multitude of physiologic processes. Other transcripts produced by GNAS are expressed exclusively from either the paternal or the maternal GNAS allele .
GNAS1 has a highly complex imprinted expression pattern. The GNAS locus is imprinted and encodes 4 main transcripts, Gs-alpha, XLAS, NESP55, and the A/B transcript, as well as an antisense GNAS transcript (GNASAS).

Organism species: Homo sapiens (Human)

Organism species: Mus musculus (Mouse)

Organism species: Rattus norvegicus (Rat)