G Protein Coupled Receptor 35 (GPR35)

G protein-coupled receptors (GPRs, or GPCRs) contain 7 hydrophobic transmembrane domains embedded in hydrophilic intra- and extracellular loops and transduce a variety of hormone, endogenous peptide, and neurotransmitter signals into intracellular effects via G proteins. O'Dowd et al. (1998) searched for genes related to GPR1 by PCR of genomic DNA with degenerate primers based on the conserved transmembrane regions. They identified the GPR35 gene, which encodes a predicted 309-amino acid protein.GPR35 expression in all fetal and adult human tissues examined, with relatively higher levels in adult lung, small intestine, colon, and stomach. The GPR35 gene consists of a single exon. Single-nucleotide polymorphisms (SNPs) in GPR35 did not show association with or linkage to type 2 diabetes.