G Protein Coupled Receptor 78 (GPR78)
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The response depended upon the cell line studied. UV-B was a weaker inducer, and UV-C and several other DNA-damaging agents did not induce GPR78 expression. Induction of GPR78 by tunicamycin required activation of multiple ER stress-response elements in the promoter of the GPR78 gene, and induction by a DNA-alkylating agent was independent of the unfolded protein response.
GPR78 encodes a deduced 363-amino acid protein that shares 56% sequence identity with GPR26 in the transmembrane region. Northern blot analysis revealed a 1.1-kb transcript in pituitary, and 1.1- and 4.2-kb transcripts in placenta. No expression was detected in brain, skeletal muscle, lung, heart, liver, pancreas, or kidney.
Organism species: Homo sapiens (Human)
- Recombinant protein RPG738Hu01 Recombinant G Protein Coupled Receptor 78 (GPR78) In Stock
- Monoclonal antibody MAG738Hu21 Monoclonal Antibody to G Protein Coupled Receptor 78 (GPR78) In Stock
- Polyclonal antibody PAG738Hu01 Polyclonal Antibody to G Protein Coupled Receptor 78 (GPR78) In Stock
- Sandwich ELISA SEG738Hu ELISA Kit for G Protein Coupled Receptor 78 (GPR78) In Stock