G-Elongation Factor, Mitochondrial 1 (GFM1)

Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA.

Elongation factor G 1, mitochondrial is one of the mitochondrial translation elongation factors. Its role in the regulation of normal mitochondrial function and in different disease states attributed to mitochondrial dysfunction is not known.This protein promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome.