G Protein Coupled Receptor Kinase 4 (GRK4)
GPRK2L; GPRK4; GRK4a; IT11; G protein-coupled receptor kinase GRK4
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G protein-coupled receptor kinase 4 is a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. G protein-coupled receptor kinases are a family of serine/threonine kinases that appear to play a role in receptor desensitization. Beta-adrenergic receptor kinase-1 and rhodopsin kinase are examples. They phosphorylate the activated form of the corresponding receptor, increasing its ability to interact with beta-arrestin or retinal arrestin, respectively. Binding of the arrestins to the receptors then blocks further activation of the respective signal transduction pathways.
Organism species: Homo sapiens (Human)
- Recombinant protein RPC193Hu01 Recombinant G Protein Coupled Receptor Kinase 4 (GRK4) In Stock
- Polyclonal antibody PAC193Hu01 Polyclonal Antibody to G Protein Coupled Receptor Kinase 4 (GRK4) In Stock
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Organism species: Mus musculus (Mouse)
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- Customized Service n/a Polyclonal Antibody to G Protein Coupled Receptor Kinase 4 (GRK4) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for G Protein Coupled Receptor Kinase 4 (GRK4) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for G Protein Coupled Receptor Kinase 4 (GRK4) ELISA Kit Customized Service Offer
Organism species: Rattus norvegicus (Rat)
- Customized Service n/a Recombinant G Protein Coupled Receptor Kinase 4 (GRK4) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to G Protein Coupled Receptor Kinase 4 (GRK4) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to G Protein Coupled Receptor Kinase 4 (GRK4) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for G Protein Coupled Receptor Kinase 4 (GRK4) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for G Protein Coupled Receptor Kinase 4 (GRK4) ELISA Kit Customized Service Offer