Galactose-3-O-Sulfotransferase 1 (GAL3ST1)

Sulfonation, an important step in the metabolism of many drugs, xenobiotics, hormones, and neurotransmitters, is catalyzed by sulfotransferases. GAL3ST1 is galactosylceramide sulfotransferase which catalyzes the conversion between 3'-phosphoadenylylsulfate + a galactosylceramide to adenosine 3',5'-bisphosphate + galactosylceramide sulfate. Activity of this sulfotransferase is enhanced in renal cell carcinoma.

The GalCer sulfotransferase cDNA encodes a 423-amino acid protein with a predicted type II transmembrane topology and 2 potential N-linked glycosylation sites. GalCer sulfotransferase is not homologous to either the cytosolic sulfotransferases or the Golgi sulfotransferases.