Ganglioside Induced Differentiation Associated Protein 1 (GDAP1)

GDAP1 encodes a member of the ganglioside-induced differentiation-associated protein family, which may play a role in a signal transduction pathway during neuronal development. Mutations in this gene have been associated with various forms of Charcot-Marie-Tooth Disease and neuropathy. Two transcript variants encoding different isoforms have been identified for this gene.

The deduced 358-amino acid human GDAP1 protein is 94% identical to the mouse protein, with most divergence at the N terminus. Northern blot analysis revealed expression of a 4.1-kb Gdap1 transcript restricted to mouse brain tissue. Immunofluorescence microscopy demonstrated cytoplasmic expression in mouse cells.