Gasdermin D (GSDMD)

Gasdermin D is a member of the gasdermin family. Members of this family appear to play a role in regulation of epithelial proliferation. Gasdermin D has been suggested to act as a tumor suppressor. Alternatively spliced transcript variants have been described.

GSDM showed apoptotic activity upon expression in a human gastric cancer cell line. LMO1, RUNX3, and TGF-beta receptor II (TGFBR2) were coexpressed with GSDM in pit cells, and both LMO1 and RUNX3 bound to the GSDM promoter in vitro. TGF-beta (TGFB1) upregulated LMO1 and GSDM expression and induced apoptosis, and induction of apoptosis was inhibited by suppression of LMO1, RUNX3, and GSDM expression.