Gigaxonin (GAN)
GAN1; KLHL16; Giant Axonal Neuropathy; Kelch-like protein 16
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GAN encodes a member of the cytoskeletal BTB/kelch (Broad-Complex, Tramtrack and Bric a brac) repeat family. (Kelch repeats are predicted to form a beta-propeller shape.) The encoded protein plays a role in neurofilament architecture and is mutated in giant axonal neuropathy.gigaxonin controls protein degradation and is essential for neuronal function and survival. gigaxonin binds to the ubiquitin-activating enzyme E1 through its amino-terminal BTB domain, while the carboxy-terminal kelch repeat domain interacts directly with the light chain (LC) of microtubule-associated protein-1B (MAP1B). Overexpression of gigaxonin leads to enhanced degradation of MAP1B-LC, which could be antagonized by proteasome inhibitors. Ablation of gigaxonin caused a substantial accumulation of MAP1B-LC in GAN-null neurons.
Organism species: Homo sapiens (Human)
- Recombinant protein RPJ068Hu01 Recombinant Gigaxonin (GAN) In Stock
- Polyclonal antibody PAJ068Hu01 Polyclonal Antibody to Gigaxonin (GAN) In Stock
- Monoclonal antibody MAJ068Hu21 Monoclonal Antibody to Gigaxonin (GAN) In Stock
- Sandwich ELISA SEJ068Hu ELISA Kit for Gigaxonin (GAN) In Stock
Organism species: Mus musculus (Mouse)
- Customized Service n/a Recombinant Gigaxonin (GAN) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Gigaxonin (GAN) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Gigaxonin (GAN) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Gigaxonin (GAN) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Gigaxonin (GAN) ELISA Kit Customized Service Offer
Organism species: Rattus norvegicus (Rat)
- Customized Service n/a Recombinant Gigaxonin (GAN) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Gigaxonin (GAN) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Gigaxonin (GAN) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Gigaxonin (GAN) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Gigaxonin (GAN) ELISA Kit Customized Service Offer