Glial Cell Line Derived Neurotrophic Factor Receptor Alpha 2 (GFRa2)

Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor.

This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. GDNF family receptor alpha-2 is a candidate gene for RET-associated diseases.Multiple transcript variants encoding different isoforms have been found for this gene.