Glucosidase Alpha, Neutral AB (GaNAB)

Human tissues contain 2 isozymes of neutral alpha-glucosidase designated AB (GANAB) and C (GANC). Initially distinguished on the basis of differences in electrophoretic mobility in starch gel, the two have been shown to have other differences including those of substrate specificity. Since the AB form of mouse is not different electrophoretically from that in man, Martiniuk et al. used rocket immunoelectrophoresis to distinguish the enzymes from the 2 species.

Trombetta et al. (1996) isolated enzymatically active glucosidase II from rat liver and found that it was composed of 2 subunits, alpha and beta. Based on peptide sequences of the purified enzyme, they identified the corresponding human cDNAs in existing sequence databases.