Glutathione S Transferase A4 (GSTA4)

Glutathione S Transferase Alpha 4 is a glutathione S-tranferase belonging to the alpha class.GSTA4 shows very high activity with reactive carbonyl compounds such as alk-2-enals.GSTA4 is highly effective in catalyzing the conjugate addition of reduced glutathione to 4-hydroxynonenal, an important product of peroxidative degradation of arachidonic acid and a commonly used biomarker for oxidative damage in tissue.Reactive electrophiles produced by oxidative metabolism have been linked to a number of degenerative diseases including Parkinson's disease, Alzheimer's disease, cataract formation, and atherosclerosis hence reduced expression of the GSTA4 enzyme may have pathophysiological consequences. The expression of this gene is decreased drastically among burn and trauma victims.