H2A Histone Family, Member V (H2AFV)

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures.

H2AFV encodes a member of the histone H2A family. Several transcript variants encoding different isoforms, have been identified for this gene.The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AFV forms an heterodimer with H2B