Heat Shock Protein 90kDa Alpha A1 (HSP90aA1)

HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. There are 2 major cytosolic HSP90 proteins, HSP90AA1, an inducible form, and HSP90AB1, a constitutive form. Other HSP90 proteins are found in endoplasmic reticulum (HSP90B1) and mitochondria (TRAP1).In humans, 2 distinct HSP90 cDNA clones were identified that hybrid-select different mRNA transcripts encoding 2 members of the HSP90 family. These were called HSP89-alpha and HSP89-beta