Heat Shock 70kDa Protein 4 (HSPA4)

Heat shock 70 kDa protein 4 is a protein that is encoded by the HSPA4 gene. The protein encoded by this gene was originally suggested to be a member of the heat shock protein 70 family. However it is now known that human HSPA4 is a equivalent to mouse the Apg-2 protein and is a member of the Hsp110 family.

Fathallah et al. (1993) reported the cloning of a human heat-shock protein (hsp), which they designated hsp70 RY.The cDNA was isolated from an EBV-transformed B-cell line from a patient with leukocyte adhesion molecule deficiency. The predicted 701-amino acid protein has an N-terminal ATP-binding domain and a C-terminal peptide-binding domain characteristic of hsp proteins. Northern blot analysis detected a 3.0-kb RNA in the patient's EBV cell line.