Histone Cluster 2, H2ac (HIST2H2AC)

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures.

HIST2H2AC is intronless and encodes a member of the histone H2A family. Collart et al. (1992) found that the H2B.1 and H2A/q genes are separated by a bidirectionally transcribed intergenic promoter region of 329 nucleotides containing consensus TATA and CCAAT boxes and an OTF1 (POU2F1) element.