Histone Deacetylase 2 (HDAC2)

Histone deacetylase 2 belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes and are responsible for the deacetylation of lysine residues on the N-terminal region of the core histones (H2A, H2B, H3 and H4). This protein also forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus it plays an important role in transcriptional regulation, cell cycle progression and developmental events.

YY1 is a mammalian zinc finger transcription factor that acts as both a positive and negative regulator of transcription at CCATNTT consensus DNA elements in promoters of cellular and viral genes.