Hut-78 T-Lymphoblastic Leukemia Cells (Hut78)

Hut-78 cells are a human T-cell lymphoblast-like cell line that has been widely used in immunology and cancer research. The Hut-78 cell line was established from the peripheral blood of a patient with Sezary syndrome, a rare and aggressive form of cutaneous T-cell lymphoma. These cells exhibit characteristics of activated T-cells and can be used as a model system for studying T-cell biology, immune responses, and cancer immunotherapy.

Hut-78 cells are often utilized to investigate T-cell signaling pathways, immune cell activation, cytokine production, and interactions with other immune cells or tumor cells. Researchers employ these cells to explore the mechanisms underlying T-cell-mediated immune responses, immune evasion strategies employed by cancer cells, and the development of novel immunotherapies for cancer treatment.

Additionally, the Hut-78 cell line has been instrumental in studying the pathogenesis of cutaneous T-cell lymphomas and identifying potential therapeutic targets for these malignancies. By analyzing the gene expression profiles, signaling pathways, and drug responses of Hut-78 cells, researchers have gained valuable insights into the molecular mechanisms driving T-cell lymphomas and have identified promising candidates for targeted therapy.