Insulin Receptor Substrate 3 (IRS3)
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Based on the phenotypes of knockout mice and cell lines, as well as pathway-specific analysis, the insulin receptor substrates IRS-1, IRS-2, IRS-3, and IRS-4 have been shown to play unique roles in insulin signal transduction. In contrast, mice with a combined deficiency of IRS-1 and IRS-3 developed early-onset severe lipoatrophy associated with marked hyperglycemia, hyperinsulinemia, and insulin resistance. However, in contrast to other models of lipoatrophic diabetes, there was no accumulation of fat in liver or muscle. Furthermore, plasma leptin levels were markedly decreased, and adenovirus-mediated expression of leptin in liver reversed the hyperglycemia and hyperinsulinemia. IRS-1 and IRS-3 play important complementary roles in adipogenesis and establish the Irs1/Irs3 double knockout mouse as a novel model of lipoatrophic diabetes.
Organism species: Mus musculus (Mouse)
- Customized Service n/a Recombinant Insulin Receptor Substrate 3 (IRS3) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Insulin Receptor Substrate 3 (IRS3) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Insulin Receptor Substrate 3 (IRS3) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Insulin Receptor Substrate 3 (IRS3) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Insulin Receptor Substrate 3 (IRS3) ELISA Kit Customized Service Offer
Organism species: Rattus norvegicus (Rat)
- Recombinant protein RPS762Ra01 Recombinant Insulin Receptor Substrate 3 (IRS3) In Stock
- Monoclonal antibody MAS762Ra21 Monoclonal Antibody to Insulin Receptor Substrate 3 (IRS3) In Stock
- Polyclonal antibody PAS762Ra01 Polyclonal Antibody to Insulin Receptor Substrate 3 (IRS3) In Stock
- Sandwich ELISA SES762Ra ELISA Kit for Insulin Receptor Substrate 3 (IRS3) In Stock