Inter Alpha-Globulin Inhibitor H1 (ITIH1)

Salier et al. (1987) characterized cDNAs for the H chain of IATI. Diarra-Mehrpour et al. (1989) showed that human poly(A)-rich RNAs hybrid-selected with various heavy-chain-encoding cDNA clones translate 3 different heavy chains, designated H1 (M(r) 92,000), H2 (ITIH2), and H3 (ITIH3). Two previously characterized heavy-chain cDNA clones were found to correspond to the H1 and H2 chains. The deduced amino acid sequence of the H3 chain was found to be highly similar to those of the H1 (54%) and H2 (44%) chains. Diarra-Mehrpour et al. (1992) used a PCR-based cloning approach and cDNA library screening to isolate the full-length cDNA H1. The results of Northern blot analysis by Bost et al. (1993) indicated that the 2.9-kb ITIH1 mRNA is expressed only in liver.