Interleukin 1 Receptor Accessory Protein Like Protein 1 (IL1RAPL1)

IL1RAPL1 is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. It is most closely related to interleukin 1 receptor accessory protein-like 2 (IL1RAPL2). This gene and IL1RAPL2 are located at a region on chromosome X that is associated with X-linked non-syndromic mental retardation. Deletions and mutations in this gene were found in patients with mental retardation.

This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities.This gene encodes a 696-amino acid protein that has homology to interleukin-1 receptor accessory proteins (IL1RAP).