Interleukin 10 Receptor Beta (IL10Rb)

Interleukin 10 receptor, beta subunit belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21.Gibbs and Pennica (1997) also cloned IL10RB by exon trapping of YAC clones spanning the interferon receptor region. The IL10RB cDNA encodes a 325-amino acid protein. Northern blot analysis revealed expression of a 2.0-kb transcript in all tissues tested except brain. Gibbs and Pennica (1997) used the human sequence to obtain the mouse cDNA.