Taxilin Alpha (TXLNa)

TXLN interacts with STX3 through its coiled-coil domain.TXLN also interacts with STX1A and STX4. Immunofluorescence and confocal microscopy demonstrated that coexpression of TXLN with STX4 caused relocalization of TXLN from the cytosol to the plasma membrane. Overexpression of TXLN in PC12 cells inhibited human growth hormone exocytosis in response to high potassium levels.  The predicted TXLN protein contains 546 amino acids and has a calculated molecular mass of 62 kD. It has a long C-terminal coiled-coil domain, 24 potential phosphorylation sites, 1 N-glycosylation site, 10 N-myristoylation sites, and 3 EF-hand motifs. Northern blot analysis detected a major 5.1-kb TXLN transcript in all tissues tested, as well as 2.1- and 1.5-kb TXLN transcripts in heart, liver, and pancreas.