Interleukin 17 Receptor A (IL17RA)

Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. IL17 induces nuclear factor kappa-B (NFKB) and the expression of IL6, intercellular adhesion molecule-1 (ICAM1), granulocyte macrophage colony-stimulating factor, and prostaglandin E2, as well as the maturation of CD34-positive hematopoietic precursors into neutrophils. IL17R is a receptor for IL17.