Interleukin 20 (IL20)

Interleukin-20 (IL-20) is a protein belonging to the IL-10 family of cytokines. IL-20 is produced by activated keratinocytes and monocytes and transmits an intracellular signal through two distinct cell-surface receptor complexes on keratinocytes and other epithelial cells. IL-20 regulates proliferation and differentiation of keratinocytes during inflammation, particularly inflammation associated with the skin.

In addition, IL-20 also causes cell expansion of multipotential hematopoietic progenitor cells.The 176-amino acid IL20 protein contains 6 conserved cysteine residues and shares 76% amino acid identity with its murine counterpart. Based on amino acid identities, IL20 is most homologous to 3 members of the IL10 family, IL19 , MDA7 , and IL10.