Intersectin 2 (ITSN2)

Intersectin-2 is thought to regulate the formation of clathrin-coated vesicles and also may function in the induction of T cell antigen receptor (TCR) endocytosis. Alternatively spliced transcript variants have been found for this gene that encode three distinct isoforms. Additional variants have been found but their full length nature has not been determined. The partial SH3D1B cDNA encodes a predicted adaptor-like protein containing at least 3 SH3 domains. SH3 domains are 60-amino acid regions of limited sequence similarity among a number of signaling and cytoskeletal proteins. Despite their modest similarity, SH3 domains share a common function: they mediate protein-protein interactions by binding short proline-rich regions in target proteins.