Keratin Associated Protein 1-4 (KRTAP1-4)

KAP1.4; High sulfur keratin-associated protein 1.4

Keratin Associated Protein 1-4 (KRTAP1-4)
The main structural proteins of mammalian hair fiber are the hair keratins and the keratin-associated proteins (KAPs), which form a rigid and resistant hair shaft through extensive disulfide bond crosslinking with the abundant cysteines of hair keratins.KRTAP1-4 gene is about 1.0 kb long and consists of a single exon.
The deduced 121-amino acid protein has a calculated molecular mass of 12.3 kD. KAP1.4 is classified as a high sulfur protein owing to a cysteine content of 24.8 mol %. It contains 2 unique motifs conserved among KAP1 family members, several characteristic pentapeptide repeats, and a 20-amino acid subdomain that was conserved among KAP1 family members in all species examined. KAP1.4 lacks an amino-terminal motif common to other members of the KAP1 family.

Organism species: Homo sapiens (Human)