Kinesin Family, Member 22 (KIF22)

KIF22 is a member of kinesin-like protein family. This family of proteins are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. The C-terminal half of this protein has been shown to bind DNA. Studies with the Xenopus homolog suggests its essential role in metaphase chromosome alignment and maintenance.The predicted 665-amino acid protein was designated KID. The N-terminal region of KID shares greater than 35% sequence homology with the motor domains of other kinesins. The C-terminal domain has limited but significant homology to NOD. KID also contains a putative nuclear localization signal. the 2.3-kb KID mRNA was expressed in all cancer cell lines tested and in various somatic tissues. In cancer cells, other faint bands were also detected.