Liraglutide (LRT)
Victoza
Liraglutide is an acylated human glucagon-like peptide-1 (GLP-1) agonist, with a 97% amino acid sequence identity to endogenous human GLP-1(7-37). GLP-1(7-37) represents less than 20% of total circulating endogenous GLP-1. Like GLP-1(7-37), liraglutide activates the GLP-1 receptor, a membrane-bound cell-surface receptor coupled to adenylyl cyclase by the stimulatory G-protein, Gs, in pancreatic beta cells. Liraglutide increases intracellular cyclic AMP (cAMP), leading to insulin release in the presence of elevated glucose concentrations. This insulin secretion subsides as blood glucose concentrations decrease and approach euglycemia. Liraglutide also decreases glucagon secretion in a glucose-dependent manner. GLP-1(7-37) has a half-life of 1.5–2 minutes due to degradation by the ubiquitous endogenous enzymes, dipeptidyl peptidase IV (DPP-IV) and neutral endopeptidases (NEP).
Organism species: Homo sapiens (Human)
- Customized Service n/a Complete Antigen of Liraglutide (LRT) Antigenic Transformation Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Liraglutide (LRT) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Liraglutide (LRT) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Liraglutide (LRT) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Liraglutide (LRT) ELISA Kit Customized Service Offer
Organism species: Pan-species (General)
- Conjugated small molecules CPV769Ge31 KLH Conjugated Liraglutide (LRT) In Stock
- Conjugated small molecules CPV769Ge21 OVA Conjugated Liraglutide (LRT) In Stock
- Polyclonal antibody PAV769Ge01 Polyclonal Antibody to Liraglutide (LRT) In Stock
- Competition ELISA CEV769Ge ELISA Kit for Liraglutide (LRT) In Stock