Lung Squamous Cell Carcinoma Cells (LSCC)

Squamous-cell carcinoma (SCC) of the lung is a type of non-small-cell lung carcinoma and is more common in men than in women. It is closely correlated with a history of tobacco smoking, more so than most other types of lung cancer. Studies suggested that the -KTS-containing variants of WT1 are directly involved in the regulation of p21Waf1/Cip1 expression and the subsequent suppression of lymph node metastasis in human lung squamous cell carcinoma. It most often arises centrally in larger bronchi, and while it often metastasizes to locoregional lymph nodes (particularly the hilar nodes) early in its course, it generally disseminates outside the thorax somewhat later than other major types of lung cancer. Large tumors may undergo central necrosis, resulting in cavitation.