Tricellulin (TRIC)
MARVELD2; DFNB49; MARVD2; MRVLDC2; MARVEL Domain Containing Protein 2; Deafness,Autosomal Recessive 49
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MARVELD2, or tricellulin (TRIC), is an integral membrane protein concentrated at the vertically oriented TJ strands of tricellular contacts.The 555-amino acid protein contains cytoplasmic N and C termini, 2 transmembrane domains, and 2 extracellular loops. Northern blot analysis detected high expression of Tric in epithelium-derived tissues, including small intestine, kidney, and lung. Western blot analysis of mouse epithelial cell lines revealed an approximately 66-kD protein, as well as larger phosphorylated intracellular forms. Immunofluorescence microscopy showed expression of Tric predominantly at tricellular contacts where occludin (OCLN)-positive bicellular TJs converged. Tric-positive structures appeared as short rods through confocal microscopy.
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
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Organism species: Rattus norvegicus (Rat)
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