Malonyl Coenzyme A Decarboxylase (MLYCD)

Malonyl-CoA decarboxylase (EC 4.1.1.9) catalyzes the conversion of malonyl-CoA to acetyl-CoA and carbon dioxide. It is thought to be involved in aspects of fatty acid biosynthesis and oxidation.

Malonyl-CoA decarboxylase is found most often in the liver, brain, heart, and skeletal muscle. Gao et al. (1999) searched expressed sequence tag databases to identify human cDNAs with homology to the goose malonyl-CoA decarboxylase cDNA sequence. The 1,479-nucleotide human cDNA sequence is 70% identical to that of goose. FitzPatrick et al. (1999) identified a 2.1-kb human MCD cDNA encoding a 454-amino acid protein that shows 70.3% amino acid identity to goose Mcd.