Mannose Receptor C Type 1 Like Protein 1 (MRC1)

The MRC1 gene is in close proximity to MRC1L1 and has a gene loci that includes the gene, MRC1L1, as well as LOC340843 and LOC340893. The gene also consist of nearly two identical regions, some think that they are duplicated regions. Recombinant proteins produced in yeast may be subject to increased addition of mannose, in patterns different from those of a human cell.

Dendritic cells take of the immune system possess a mannose receptor that enables them to take up mannosylated proteins, and utilize fragments of them for antigen presentation. The macrophage mannose receptor also interacts with HIV proteins. These interactions affect the gp120 and its ability to bind to the B cells through MRC1 receptors and an increase production of matrix mannose receptors