Mitogen Activated Protein Kinase Kinase Kinase 6 (MAP3K6)
MAPKKK6; ASK2; MEKK6; Apoptosis Signal Regulating Kinase 2
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MAP3K6 is a member of the serine/threonine protein kinase family. The encoded kinase was identified by its interaction with MAP3K5/ASK, a protein kinase and an activator of c-Jun kinase (MAPK7/JNK) and MAPK14/p38 kinase. This kinase was found to weakly activate MAPK7, but not MAPK1/ERK or MAPK14. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined.
MAP3K6 and MAP3K5 share 45% amino acid sequence identity; their catalytic domains share 82% identity. The authors confirmed the interaction of MAP3K6 with MAP3K5 in vivo using coimmunoprecipitation. Recombinant MAP3K6 weakly activated the JNK but not the ERK or p38 kinase pathways.
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
- Customized Service n/a Recombinant Mitogen Activated Protein Kinase Kinase Kinase 6 (MAP3K6) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Mitogen Activated Protein Kinase Kinase Kinase 6 (MAP3K6) Monoclonal Antibody Customized Service Offer
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- Customized Service n/a CLIA Kit for Mitogen Activated Protein Kinase Kinase Kinase 6 (MAP3K6) CLIA Kit Customized Service Offer
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Organism species: Rattus norvegicus (Rat)
- Recombinant protein RPD558Ra01 Recombinant Mitogen Activated Protein Kinase Kinase Kinase 6 (MAP3K6) In Stock
- Polyclonal antibody PAD558Ra01 Polyclonal Antibody to Mitogen Activated Protein Kinase Kinase Kinase 6 (MAP3K6) In Stock
- Monoclonal antibody MAD558Ra21 Monoclonal Antibody to Mitogen Activated Protein Kinase Kinase Kinase 6 (MAP3K6) In Stock
- Sandwich ELISA SED558Ra ELISA Kit for Mitogen Activated Protein Kinase Kinase Kinase 6 (MAP3K6) In Stock