Mitogen Activated Protein Kinase Kinase Kinase 9 (MAP3K9)

Mitogen-activated protein kinase kinase kinase 9 is an enzyme encoded by the MAP3K9 gene.While protein kinases vary widely in their primary structures, each contains a catalytic domain of 250 to 300 amino acids, which includes 11 highly conserved motifs or subdomains separated by sequences of amino acids with reduced conservation.

The presence of these motifs within a newly characterized sequence is, therefore, strongly predictive of PK activity. Furthermore, specificity of a PK for phosphorylation of either tyr or ser/thr can be predicted by the sequence of 2 of the motifs (VIb and VIII) in which different residues are conserved in each class.