Temporomandibular Osteoarthrosis (TO)

Temporomandibular joint osteoarthrosis or temporomandibular joint dysfunction(TMD) is an umbrella term covering pain and dysfunction of the muscles of mastication and the temporomandibular joints. The most important feature is pain, followed by restricted mandibular movement, and noises from the temporomandibular joints (TMJ) during jaw movement. Although TMD is not life-threatening, it can be detrimental to quality of life, because the symptoms can become chronic and difficult to manage.TMD is a symptom complex rather than a single condition, and it is thought to be caused by multiple factors. However, these factors are poorly understood. Studies showed that mice Deficient in Biglycan and Fibromodulin was as a Model for Temporomandibular Joint Osteoarthritis.