Myosin Light Chain 6, Alkali, Smooth Muscle And Non Muscle (MYL6)

Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. MYL6 is a myosin alkali light chain that is expressed in smooth muscle and non-muscle tissues. Genomic sequences representing several pseudogenes have been described and two transcript variants encoding different isoforms have been identified for this gene.

Both deduced proteins contain 151 amino acids and differ from other MLCs in that they lack highly basic amino aids in their N termini. MLC3NM has a calculated molecular mass of 16.9 kD, whereas MLC3SM has a calculated molecular mass of 17 kD. Expression of MYL6 was highest in fibroblasts and myoblasts, lower in fetal muscle, and lowest in adult muscle.