N-Methylpurine DNA Glycosylase (MPG)

AAG; APNG; ADPG; CRA36.1; MDG; Mid1; PIG11; PIG16; Anpg; DNA-3-Methyladenine Glycosylase; Alkyladenine DNA Glycosylase; 3-alkyladenine DNA glycosylase

N-Methylpurine DNA Glycosylase (MPG)
The bacterial enzyme 3-methyladenine (3MeA) DNA glycosylase repairs the lethal lesion 3MeA that blocks DNA replication in Escherichia coli. The removal of 3MeA is mediated by two 3MeA DNA glycosylases in E. coli, encoded by the alkA and tag genes.
The cDNA hybridized to human genomic DNA but did not hybridize to E. coli or yeast DNA. DNA sequence analysis defined an open reading frame coding for a 33-kD protein that showed extensive amino acid homology with rat 3MeA DNA glycosylase. The gene (designated N-methylpurine DNA glycosylase, MPG) was mapped to human chromosome 16 by analysis of a panel of DNAs from mouse/human and hamster/human hybrid cell lines.

Organism species: Homo sapiens (Human)

Organism species: Mus musculus (Mouse)

Organism species: Rattus norvegicus (Rat)