Nasal Mucosa Fibroblasts (NMF)

Nasal mucosa fibroblasts are crucial stromal cells within the nasal mucosa that contribute significantly to extracellular matrix (ECM) production and tissue repair processes. These cells are recognized for their multifaceted roles in inflammation, wound healing, and fibrosis, impacting various pathological conditions of the nasal cavity, such as chronic rhinosinusitis (CRS), allergic rhinitis (AR), and nasal polyposis (NP).

Fibroblasts are the primary supporting cells in connective tissue and have historically been considered critical for contributing to conditions like chronic rhinosinusitis with nasal polyps (CRSwNP) by producing ECM, leading to fibrosis and tissue remodeling. However, contemporary research highlights their active role not merely as structural components but as key players in initiating and exacerbating inflammatory responses. For example, nasal polyp-derived fibroblasts (NPDFs) have been shown to trigger and intensify inflammation in CRSwNP.