Never In Mitosis Gene A Related Kinase 7 (NEK7)

NIMA-related kinases share high amino acid sequence identity with the gene product of the Aspergillus nidulans 'never in mitosis A' gene, which controls initiation of mitosis.

The deduced 302-amino acid protein has a predicted molecular mass of 34.5 kD. It contains 12 conserved regions characteristic of protein kinase catalytic domains, including a DIKPAN motif that suggests serine/threonine kinase activity. Human NEK7 shares 97%, 77%, 77%, and 64% sequence identity with mouse Nek7, human NEK6 , mouse Nek6, and C. elegans F19H6.1. highest expression of NEK7 in lung, muscle, testis, brain, heart, liver, leukocyte, and spleen. Faint bands were detected in ovary, prostate, and kidney, and no transcript was amplified from small intestine.