Nuclear Factor Related To Kappa B Binding Protein (NFRkB)

Nuclear factor related to kappa-B-binding protein is a protein encoded by the NFRKB gene.Nuclear factor-kappa-B (NFKB1; NFKB2) binds in vitro to several of the kappa-B regulatory elements found in cellular and viral genes. Another DNA binding protein, R-kappa-B, binds to a related variant of the kappa-B site that regulates interleukin-2 receptor alpha-chain (IL2RA) gene expression, a critical event in T-cell activation.

By Southern blot analysis of a human-mouse somatic cell hybrid panel and in situ hybridization using a fluorescent genomic probe, Adams et al. (1992) mapped the NFRKB gene to 11q24-q25. It was the most telomeric marker identified up to that point on 11q.